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Better Health News and Comment
VOLUME FOUR, NUMBER FIVE                        NEWSLETTER HOME

Autism, ADHD and Food Allergies
Autism, ADHD and Food Allergies

Lowering Cholesterol: Niacin Works, Mercks Zetia Does Not
Lowering Cholesterol: Niacin Works, Mercks Zetia Does Not

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Natural or Organic - Know How to Read the Labels

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Top 5 Sleep Supplements

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Decreased Strengh and Fat in Young People Linked to Low Vitamin D
Decreased Strengh and Fat in Young People Linked to Low Vitamin D

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Urban Gardening
Urban Gardening

Pig Business is Big Business
Pig Business is Big Business

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Mainstream Media Plays Catch-Up on Chemicals
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Plastic Ocean - Toxic Garbage Island
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Fighting Austism With Food
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Fighting Austism With Food
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What is Natural?
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The Grocery Cart As Weapon
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Moods and the Immune System
Moods and the Immune System

Tumors and Death by Cell Phone
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Top Ten Heart Health Supplements
Top Ten Heart Health Supplements

Liver and Kidney Damage from GMO Crops
Liver and Kidney Damage from GMO Crops

Vitamin D Levels during the Winter
Vitamin D Levels during the Winter

The Value Of Nothing
The Value Of Nothing

Reclaiming Domesticity from a Consumer Culture
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Lowering Cholesterol: Niacin Works, Mercks Zetia Does NotLowering Cholesterol: Niacin Works, Mercks Zetia Does Not

A new study confirms Niacin's cholesterol lowering ability and the uselessness of Mercks drug Zetia.

BioScienceTechnology | Marilynn Marchione | A new study raises fresh concerns about Zetia and its cousin, Vytorin drugs that are still taken by millions of people to lower cholesterol, despite questions raised last year about how well they work.

In the study, Zetia, the brand name for ezetimibe, failed to shrink buildups in artery walls while a rival drug, Niaspan, generically known as niacin, did so significantly. Zetia users also suffered more heart attacks and other problems although the numbers of these events are too small to draw firm conclusions.

Vytorin is a pill that combines Zetia with a statin, simvastatin.

Zetia "has been on the market for about seven years and we still haven't proven that it improves clinical outcomes," said Dr. Roger Blumenthal, preventive cardiology chief at Johns Hopkins University. The new results will be "very influential" in getting more doctors to turn to Niaspan, he said.

He wrote an editorial accompanying the results, which were presented Sunday at an American Heart Association conference and being published Monday by the New England Journal of Medicine.

The study is too limited to warrant changing practice on its findings alone, many heart experts said. Patients also should not stop taking any heart medicine without checking with their doctors first, they warn.

Statins such as Lipitor and Crestor have long been used to lower LDL, or bad cholesterol, and are known to cut the risk of heart problems. Nevertheless, many statin users still suffer heart attacks, so doctors have been testing adding a second medicine to further lower risk.

One they are trying is Niaspan, a slow-release version of niacin, a type of B vitamin that raises HDL, or good cholesterol. Another is Zetia, which lowers bad cholesterol in a different way than statins do, by blocking its absorption in the gut.

Zetia and Vytorin, the pill that combines Zetia with a statin, are both sold by Merck&Co. of Whitehouse Station, New Jersey. Niaspan is made by North Chicago, Illinois-based Abbott Laboratories. All three of these drugs cost between $3 and $4 a day, though niacin has been sold as a cheap generic for decades.

The new study was sponsored by Abbott, and several study leaders have been paid speakers or consultants to the company or to rival drugmakers.

Researchers enrolled 363 people with heart disease or a high risk for it who had been taking statins for six years on average. Many were from Walter Reed Army Medical Center, where study leader Dr. Allen Taylor formerly worked.

Half were given Niaspan and the rest, Zetia. Researchers stopped the study in June, after 208 participants had been on the medicines for 14 months, because one group was faring much better than the other.

Ultrasound images of neck arteries showed that Niaspan shrank buildups by about 2 per cent, while Zetia had no effect on this even though it lowered bad cholesterol as expected.

There were two heart attacks, heart-related deaths or other heart-related problems in the 160 people given Niaspan, and nine among the 165 on Zetia.

"It should be better for the arteries and it wasn't," Taylor said of Zetia. "The drug wasn't operating as you otherwise would expect it to," raising concern that its effects are not fully understood, he said.

Merck's research chief, Peter Kim, said the study and especially the number of heart attacks and other problems are too small to be conclusive. More than 25,000 people are in studies testing Zetia now, and independent monitors have found no problems that would lead them to stop the trials.

"We stand behind the safety of this drug," he said.

Kenneth Frazier, Merck's president of global human health, said: "The question is, how important is the study?" Shrinking plaque is no guarantee that heart attacks will be prevented, and not all studies have found a correlation, he said.

However, the difference in plaque that Niaspan made in this study "is precisely the same as the difference" that earlier studies found from statins, which are now known to save lives, said Dr. James Stein, a University of Wisconsin-Madison cardiologist. He is a leading researcher on imaging artery buildups and in the past consulted for Schering-Plough Corp., which used to market Vytorin with Merck.

Dr. Sidney Smith, a former heart association president from the University of North Carolina at Chapel Hill, said that for people with newly diagnosed cholesterol problems, "the foundation is still statins."

The new study "affirms the benefits of niacin" and makes it the next drug to add if people need more help beyond what statins can provide, he said.

Last year, a large study found that the combo pill Vytorin was no more effective than Zocor alone, a statin now available as a generic for a fraction of Vytorin's cost. In August, Merck and Schering-Plough agreed to pay $41.5 million to settle lawsuits claiming they delayed unfavourable study results on the drugs because they would hurt sales.

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