Popular Natural Anti-Depression Supplements
St. John's wort
St. John's wort is also known as Hypericum perforatum. This plant has been a common herbal mental health treatment for hundreds of years. However, people must use caution if they chose to try it as a potential treatment for depression.
A 2016 systematic review found that St. John's wort was more effective than a placebo for treating mild to moderate depression and worked almost as well as antidepressant medications.
However, this review of eligible studies did not find research on the long-term effects of St. John's wort on severe depression.
The authors also advised caution against accepting the results wholesale, as the herb has adverse effects that many of the studies did not consider.
St John's wort can also interfere with the effects of antidepressant medication, meaning that it may make symptoms worse or reduce the effectiveness of conventional treatment.
While St. John's wort might help some people, it does not show consistently beneficial effects.
For these reasons, people should not use St. John's wort instead of conventional treatment. Neither should they try St. John's wort to treat moderate to severe depression.
View all St. John's Wort Products
2. Ginseng
This supplement comes from the gnarled root of the American or Asian ginseng plant. Siberian, Asian, and Eleuthero ginseng are different plants with different active ingredients.
Practitioners of Chinese medicine have used ginseng for thousands of years to help people improve mental clarity and energy and reduce the effects of stress.
Some people associate these properties of ginseng with potential solutions for the low energy and motivation that can occur with depression.
However, the National Center for Complementary and Integrative Health (NCCIH) advise that none of the many studies that people have conducted on ginseng have been of sufficient quality to form health recommendations.
3. Chamomile
A study in 2012 reviewed data about chamomile, which comes from the Matricaria recutita plant, and its role in helping to manage depression and anxiety.
The results show that chamomile produced more significant relief from depressive symptoms than a placebo. However, further studies are necessary to confirm the health benefits of chamomile in treating depressive symptoms.
4. Lavender
Lavender oil is a popular essential oil. People typically use lavender oil for relaxation and reducing anxiety and mood disturbances.
A 2013 review of various studies suggested that lavender might have significant potential in reducing anxiety and improving sleep.
Lavender has mixed results in studies that assess its impact on anxiety. However, its effectiveness as a treatment for ongoing depression has little high-quality evidence in support at the current time.
5. Saffron
Some studies cite using saffron as a safe and effective measure for controlling the symptoms of depression, such as this non-systematic review from 2018.
However, more research would help confirm the possible benefits of saffron for people with depression. Scientists also need to understand any possible adverse effects better.
6. SAMe
SAMe is short for S-adenosyl methionine. It is a synthetic form of a chemical that occurs naturally in the body.
In 2016, researchers reviewed all the randomized controlled trials on record for the use of SAMe to treat depression in adults. They found no significant difference between the effects of SAMe on depression symptoms and those of a placebo.
However, they also found that SAMe had about the same effectiveness as the common antidepressants imipramine or escitalopram. Furthermore, it was better than a placebo when the researchers mixed SAMe with selective serotonin reuptake inhibitor medications.
As with many other studies into herbs and supplements, the investigations into the safety and efficacy of SAMe are of low quality. More research is necessary to determine its exact effect.
People use the supplement in Europe as a prescription antidepressant. However, the FDA have not yet approved this for use in the U.S.